Fig. 6. The myotube-dependent regulation of FAP differentiation is altered in DMD. DMD FAPs were cultured alone or with DMD MPs (DMD co-cult) (A) or with Healthy MPs (DMD/Healthy co-cult) (B) for 10 days in differentiation medium. (C) Healthy FAPs were cultured alone or with DMD MPs (Healthy/DMD co-cult) for 10 days in differentiation medium. Expression of FABP4, COL1A1 and FN1 was measured by quantitative Q-PCR (n=6 DMD donors and n=3 healthy donors). *** P<0.001; ** P<0.01; * P<0.05; ns= non-significant; p values closed to significance are indicated.